IPAG
CAS No. : 193527-91-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $980 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100985 |
| M.Wt: | 395.28 |
| Formula: | C17H22IN3 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic;adjust pH to 3 with 1M HCl;heat to 60°C) |
IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2].
In Vitro: Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[2].
IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass[3].
IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[3].
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