Capromorelin (Tartrate)
CAS No. : 193273-69-7
(Synonyms: CP 424391-18)
| Size | Price | Stock |
|---|---|---|
| 2mg | $50 | In-stock |
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $260 | In-stock |
| 50mg | $460 | In-stock |
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| Cat. No. : | HY-15243 |
| M.Wt: | 655.70 |
| Formula: | C32H41N5O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a. IC50 & Target: Ki: 7 nM (hGHS-R1a)[2] In Vitro: Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM[2]. In Vivo: Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group[1]. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][2]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv[2].
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