PC945
CAS No. : 1931946-73-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $680 | In-stock |
| 50mg | $1980 | In-stock |
| 100mg | $2750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117766 |
| M.Wt: | 682.73 |
| Formula: | C38H37F3N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2].
In Vitro: PC945 is a triazole antifungal designed for administration via inhalation[1].
PC945 exhibits the most potent antifungal activity on azole-susceptible strain NCPF2010 with the MIC value of 0.063?μg/mL[2].
In Vivo: PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior[1].
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- PC945
- Cat. No.:
- HY-117766
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