ZM323881
CAS No. : 193001-14-8
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| Cat. No. : | HY-15467 |
| M.Wt: | 375.40 |
| Formula: | C22H18FN3O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ZM323881 is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. IC50 & Target: IC50: 2 nM (VEGFR2)[1] In Vitro: ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC50>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC50=8 nM) and VEGFR2 tyrosine phosphorylation[1]. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM[2].
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