ZM323881 (hydrochloride)
CAS No. : 193000-39-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $79 | In-stock |
| 10mg | $143 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $740 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15467A |
| M.Wt: | 411.86 |
| Formula: | C22H19ClFN3O2 |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 50 mg/mL |
ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. IC50 & Target: IC50: 2 nM (VEGFR2)[1] In Vitro: ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC50>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC50=8 nM) and VEGFR2 tyrosine phosphorylation[1]. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM[2]
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