LY310762
CAS No. : 192927-92-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $56 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $308 | In-stock |
| 100mg | $460 | In-stock |
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| Cat. No. : | HY-13527 |
| M.Wt: | 430.94 |
| Formula: | C24H28ClFN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 18.33 mg/mL (ultrasonic) |
LY310762 is a selective 5-HT1D receptor antagonist (Ki=249 nM) with a weak affinity for 5-HT1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HTSumatriptan (HY-B0121B)-induced decrease in excitatory postsynaptic potential (EPSC) amplitude[1][2][3]. In Vitro:LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM[1].
LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential)[3]. In Vivo:LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo[1].
LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model[2].
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