ML418
CAS No. : 1928763-08-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $288 | In-stock |
| 50mg | $460 | In-stock |
| 100mg | $740 | In-stock |
| 250mg | $1335 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-122697 |
| M.Wt: | 377.87 |
| Formula: | C19H24ClN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic) |
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders.
IC50 & Target:IC50: 0.31 μM (Kir7.1)[1]
In Vitro:ML418 has inhibitory activity for Kir7.1 dose-dependently with an IC50 value of 0.31 μM[1].
ML418 has selectivity for Kir7.1 and Kir6.2/SUR1 with IC50 values of 1.3 μM and 1.9 μM, respectively[1].
In Vivo:ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution[1].
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