C527
CAS No. : 192718-06-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $288 | In-stock |
| 100mg | $460 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12988 |
| M.Wt: | 293.25 |
| Formula: | C17H8FNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL |
C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM). IC50 & Target: 0.88 μM (USP1)[1] In Vitro: Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro. However, the IC50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents[1].
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