PD-166866
CAS No. : 192705-79-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $33 | In-stock |
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $384 | In-stock |
| 100mg | $576 | In-stock |
| 500mg | $1170 | In-stock |
| 1g | $1650 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-101296 |
| M.Wt: | 396.44 |
| Formula: | C20H24N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM. IC50 & Target: IC50: 52.4 nM (hFGFR1 tyrosine kinase)[1] In Vitro: PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with an IC50 value of 52.4 nM and is characterized as an ATP competitive inhibitor of the FGFR-1. PD 166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase. PD 166866 also inhibits bFGF-induced tyrosine phosphorylation of the 44- and 42-kDa (ERK 1/2) mitogen-activated protein kinase isoforms in L6 cells. Daily exposure of PD 166866 to L6 cells at concentrations from 1 to 100 nM results in a concentration-related inhibition of bFGF-stimulated cell growth for 8 consecutive days with an IC50 value of 24 nM[1].
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