GNE-371
CAS No. : 1926986-36-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $480 | In-stock |
| 10mg | $800 | In-stock |
| 25mg | $1550 | In-stock |
| 50mg | $2500 | In-stock |
| 100mg | $3800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112803 |
| M.Wt: | 431.49 |
| Formula: | C24H25N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). IC50 & Target: IC50: 10 nM (TAF1(2))[1]. In Vitro: GNE-371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies[1].
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