Leteprinim (potassium)
CAS No. : 192564-13-9
(Synonyms: AIT-082)
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| Cat. No. : | HY-120251A |
| M.Wt: | 365.39 |
| Formula: | C15H12KN5O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4].
In Vitro:Leteprinim (5-50 ng/mL, 24 and 48 h) potassium enhances neurotransmitter release, increases secretion of synaptophysin in PC12 cells[2].
In Vivo:Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].
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