11,12-DiHETrE

11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension^{[1][2][3][4][5]}. In Vitro:11,12-DiHETrE can serve as a pharmacodynamic biomarker for soluble epoxide hydrolase (sEH) inhibitors: its levels decrease after administration of sEH inhibitors^[1].
11,12-DiHETrE concentrations in plasma of patients with non-alcoholic steatohepatitis (NASH) are significantly higher than those in patients with non-alcoholic fatty liver (NAFL) and healthy controls^[2].
11,12-DiHETrE is significantly positively correlated with the presence of resting pulmonary arterial hypertension^[3].
The higher the exposure level of 11,12-DiHETrE in umbilical cord blood, the more likely it is for individuals to present with severe autism spectrum disorder (ASD) symptoms^[4].
Elevated levels of 11,12-DiHETrE reflect an imbalance in the pro-resolving/anti-inflammatory pathway^[5].