CCG-232601


CAS No. : 1922099-21-5

1922099-21-5
Price and Availability of CAS No. : 1922099-21-5
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Cat. No. : HY-111432
M.Wt: 455.88
Formula: C24H20ClF2N3O2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1922099-21-5 :

CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma[1]. In Vitro: CCG-232601 inhibits SRE.L activity with an IC50 of 0.55 µM[1]. In Vivo: CCG-232601 (50 mg/kg; i.g.; intracutaneous injections of bleomycin; daily for 14 days) inhibits bleomycin-induced skin fibrosis in mice[1].

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