CCG-222740
CAS No. : 1922098-69-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $121 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $500 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-121750 |
| M.Wt: | 444.86 |
| Formula: | C23H19ClF2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].
IC50 & Target: Rho/MRTF pathway[1]
In Vitro: CCG-222740 (10, 20 μM; for 72 hours) increases the protein levels of p27 and decreases cyclin D1. CCG-222740 decreases cell viability of CAFs, with an IC50 of ~10 μM[1].
CCG-222740 (10, 25 μM) is potent at decreasing αSMA protein expression in human conjunctival fibroblasts[2].
CCG-222740 has an IC50 of 5 μM in a fibroblast-mediated collagen contraction assay, and it is less cytotoxic[2].
In Vivo: CCG-222740 (oral gavage; 100 mg/kg/day for 7 days) significantly reduces α-SMA levels in the pancreas of caerulein-stimulated KC mice[1].
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