LY3295668
CAS No. : 1919888-06-4
(Synonyms: AK-01)
| Size | Price | Stock |
|---|---|---|
| 1mg | $105 | In-stock |
| 5mg | $256 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $620 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1150 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-114258 |
| M.Wt: | 489.95 |
| Formula: | C24H26ClF2N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 80 mg/mL (ultrasonic;warming;heat to 60°C) |
LY3295668 (AK-01) is a highly specific and orally active inhibitor of Aurora-A kinase with a Ki values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis. LY3295668 avoids the formation of polyploids related to AurB inhibition. LY3295668 can be used for the study of small cell lung cancer[1][2]. IC50 & Target:Ki: 0.8 nM (AurA)[1]. In Vitro:LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].
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