NCT-503 (Standard)
CAS No. : 1916571-90-8
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| Cat. No. : | HY-101966R |
| M.Wt: | 408.48 |
| Formula: | C20H23F3N4S |
| Purity: | >98 % |
| Solubility: |
NCT-503 (Standard) is the analytical standard of NCT-503 (HY-101966). This product is intended for research and analytical applications. NCT-503 is a blood-brain barrier-permeable, non-competitive PHGDH inhibitor with an IC50 of 2.5 μM against human PHGDH. NCT-503 reduces glucose-derived serine production and the incorporation of one-carbon units into nucleotides without decreasing PHGDH protein expression. NCT-503 prevents high selenium-induced insulin resistance in mice by regulating blood glucose and insulin levels and improving glucose tolerance, and also inhibits the growth of tumors overexpressing PHGDH. NCT-503 can be used in research related to insulin resistance and breast cancer[1][2]. IC50 & Target:IC50: 2.5 μM (PHGDH)[1]
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