SIB-1553A
CAS No. : 191611-89-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $115 | In-stock |
| 5mg | $285 | In-stock |
| 10mg | $460 | In-stock |
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| Cat. No. : | HY-107676 |
| M.Wt: | 273.82 |
| Formula: | C13H20ClNOS |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 27.38 mg/mL |
SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders[1][2].
In Vitro: SIB-1553A displaces the binding of [H]nicotine (NIC) to the rat brain nAChRs with an IC50 value of 110 nM[1].
In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency[2].
In Vivo: SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3].
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