Tenecteplase


CAS No. : 191588-94-0

(Synonyms: TNK-tPA)

191588-94-0
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Cat. No. : HY-108845
M.Wt: 1000.00
Formula: N/A
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 191588-94-0 :

Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke[1][2]. In Vitro:Tenecteplase exhibits relatively slight cytotoxicity to neuronal cells compared to its parent compound Alteplase (HY-108865)[3]. In Vivo:Tenecteplase (0.25-2.5 mg/kg, iv, single dose) reduces infarct volume when administered in the first 30 minutes, ameliorates thrombin-induced ischemic thromboembolism in mouse model[3].

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