Pecavaptan
CAS No. : 1914998-56-3
(Synonyms: BAY 1753011)
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| Cat. No. : | HY-109133 |
| M.Wt: | 543.33 |
| Formula: | C22H19Cl2F3N6O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema[1].
In Vivo: Pecavaptan (0.01, 0.03, 0.1 and 0.3 mg/kg; IV; single dose) protects from arginine vasopressin (AVP)-mediated cardiac output (CO) in canine tachypacing-induced model of heart failure (HF)[1].
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