ROMK-IN-32
CAS No. : 1914944-54-9
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| Cat. No. : | HY-124687 |
| M.Wt: | 452.50 |
| Formula: | C24H28N4O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM[1].
In Vitro: ROMK-IN-32 (compound 32) exhibits weak human SERT activity (IC50 10.4 μM; hSERT/hROMK EP=612x)[1].
In Vivo: ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model[1].
ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats[1].
ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg)[1].
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- Cat. No.:
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