5-NIdR
CAS No. : 191421-10-0
(Synonyms: 1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole)
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 250mg | $110 | In-stock |
| 1g | $212 | In-stock |
| 5g | $805 | In-stock |
| 10g | $1300 | Get quote |
| 25g | $3085 | Get quote |
| 50 g | Get quote | |
| 100 g | Get quote | |
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| Cat. No. : | HY-115567 |
| M.Wt: | 278.26 |
| Formula: | C13H14N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].
In Vitro: 5-NIdR (12.5-100 μM; 24-72 h) inhibits the growth of human glioblastoma cell lines (U87, A172, and SW1088) in a dose-dependent manner[1].
5-NIdR (1-100 μg/mL; 72 h) induces cell apoptosis in U87 cells, and arrests cell cycle at G0 phase with 100 μg/mL overnight incubation[1].
In Vivo: 5-NIdR (100 mg/kg; ip; for 5 consecutive days), together with Temozolomide (40 mg/kg), results complete tumor regression in a murine xenograft model of glioblastoma. Temozolomide alone only delayed tumor growth[1].
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