KN-93 (phosphate)
CAS No. : 1913269-12-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $66 | In-stock |
| 5mg | $132 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $665 | In-stock |
| 100mg | $960 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15465B |
| M.Wt: | 599.03 |
| Formula: | C26H32ClN2O8PS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
KN-93 phosphate is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM[1]. IC50 & Target:Ki: 370 nM (CaMK-II) In Vitro:After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts[1]. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space[2]. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93[3].
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