PI3Kδ-IN-1
CAS No. : 1911564-39-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $390 | In-stock |
| 25mg | $660 | In-stock |
| 50mg | $940 | In-stock |
| 100mg | $1280 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101921 |
| M.Wt: | 471.44 |
| Formula: | C22H20F3N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM. IC50 & Target: IC50: 1.7 nM (PI3Kδ)[1] In Vitro: PI3Kδ-IN-1 (compound 52) shows >100-fold selectivity over the other PI3K isoforms. Kinome selectivity is also excellent with >660-fold selectivity over MNK1 and others in HTRF assays. Importantly, PI3Kδ-IN-1 has an improved human/rodent in vitro stability correlation and a good permeability profile[1]. In Vivo: PI3Kδ-IN-1 (2, 5 mg/kg, orally b.i.d. for 42 days) shows greater than 50% suppression of paw swelling in mice. PI3Kδ-IN-1 has an EC50 of 10 nM at 24 h (ED50 of ∼1.25 mg/kg) in mice[1].
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