K-7174

K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer^[1][2][3]. In Vitro:K-7174 (10 μM; 1 h) inhibits the adhesion by VCAM-1 and its ligand^[1].
K-7174 (1-30 μM; 1 h) dose-dependently suppresses the VCAM-1 expression with an IC₅₀ value of 14 μM^[1].
K-7174 (1-30 μM; 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC₅₀ value of 9 μM^[1].
K-7174 (10-20 μM; 24 h) dose-dependently rescues Epo production by Hep3B cells^[2].
K-7174 (2.5-30 μM; 24 h) inhibits the binding activity of GATA^[2].
K-7174 (0-25 μM; 72 h) inhibits MM cells growth and induces cell apoptosis^[3]. In Vivo:K-7174 (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α^[2].
K-7174 (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo^[3].
K-7174 (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection^[3].