J 104871
CAS No. : 191088-19-4
(Synonyms: J-104135)
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| Cat. No. : | HY-19301 |
| M.Wt: | 708.67 |
| Formula: | C38H32N2O12 |
| Purity: | >98 % |
| Solubility: |
J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of farnesyl pyrophosphate (FPP)[1].
In Vitro:J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of 0.6 μM farnesyl pyrophosphate (FPP), whereas it scarcely inhibits rat brain protein geranylgeranyltransferase-I or squalene synthase (SS)[1].
J 104871 also inhibits Ras processing in activated H-ras-transformed NIH3T3 cells with an IC50 value of 3.1 μM[1].
In Vivo:J 104871 (40-80 mg/kg; ip; once daily; 6 days) suppresses tumor growth in a nude mouse xenograft model[1].
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