Gracillin
CAS No. : 19083-00-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $165 | In-stock |
| 50mg | $258 | In-stock |
| 100mg | $380 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-N0706 |
| M.Wt: | 885.04 |
| Formula: | C45H72O17 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy[1][2].
In Vitro:Gracillin (0-10 μM, 6-24 h) shows broad-spectrum inhibitory effects on the cancer cell viability[1].
Gracillin (5 μM) disrupts mitochondrial function, specifically, inhibits ATP production, activates AMPK, inhibits oxygen consumption rate (OCR) in H460 and A549 cells[1].
Gracillin (0-10 μM, 6 h) induces ROS generation (indicated by H2DCF-DA) in H460, H1299, H226B and A549 cells[1].
Gracillin (0-4 μM, 24 h) blocks cell cycle in G1 phase, and induces apoptosis and autophagy in A549 cells[2][3].
In Vivo:Gracillin (oral gavage, 10 mg/kg for xenografts and 20 mg/kg for PDX) inhibits tumor growth of xenograft tumors inoculating lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors[1].
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