Prosapogenin A
CAS No. : 19057-67-1
(Synonyms: Progenin III)
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 50mg | $500 | In-stock |
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| Cat. No. : | HY-N6940 |
| M.Wt: | 722.90 |
| Formula: | C39H62O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis[1].
In Vitro:Prosapogenin A (0-15 µM, 48 h) arrests the cell cycle of HepG2 at G2/M phase, inhibits the growth of cancer cells HeLa, MCF-7 and HepG2 with IC50s of 9.27, 9.36 and 8.41 µM, respectively[1].
Prosapogenin A (2–10 µM, 24 h) activates V-ATPase and caspase 3/8 pathway, triggers increased lysosomal membrane permeability (LMP), and induces a GSDME-dependent pyroptosis in anaplastic thyroid cancer cells 8505C, KHM-5M, C643, BHT-101, and HTh-7[2].
In Vivo:Prosapogenin A (10-20 mg/kg, ip, once daily for 14 days) exhibits antitumor efficacy in 8505C xenograft mouse models[2].
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