KDM5A-IN-1
CAS No. : 1905481-36-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $500 | In-stock |
| 50mg | $1500 | In-stock |
| 100mg | $2100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100014 |
| M.Wt: | 290.36 |
| Formula: | C15H22N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL (172.20 mM) |
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B)[1]. IC50 & Target: IC50: 45 nM (KDM5A), 56 nM (KDM5B) and 55 nM (KDM5C)[1] In Vivo: KDM5A-IN-1 (Compound 50, 5 mg/kg; oral administration; female CD-1 mice) treatment shows moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34) and remarkably low plasma protein binding in mice (40%), with t1/2 of 0.4 hours[1].
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Inquiry Information- Product Name:
- KDM5A-IN-1
- Cat. No.:
- HY-100014
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