AZD9362
CAS No. : 1905412-80-7
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| Cat. No. : | HY-100038 |
| M.Wt: | 494.98 |
| Formula: | C24H27ClN8O2 |
| Purity: | >98 % |
| Solubility: |
AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer[1].
In Vivo:AZD9362 (25 mg/kg, p.o.) enhances the anti-tumor effect of AZD5363 (HY-15431) in MCF-7/LTED cells and MCF-7 xenografts in ovariectomized mice devoid of estrogen supplementation[1].
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- AZD9362
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