PD-168077
CAS No. : 190383-31-4
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| Cat. No. : | HY-21098 |
| M.Wt: | 334.41 |
| Formula: | C20H22N4O |
| Purity: | >98 % |
| Solubility: |
PD-168077 is a selective dopamine D4 receptor agonist, with a Ki of 9 nM[1]. In Vitro:In the PD-168077-treated cell, p-CaMKII exhibits a significantly increased clustering at synaptic sites, as indicated by the enhanced colocalization with PSD-95[2]. In Vivo:PD-168077 (0.2-25.0 mg/kg) dose-dependently induces locomotion, which takes an unusual and characteristic ”shuffling” form with uncoordinated movements together with yawning, and episodes of myoclonic jerking; grooming, and rearing are reduced[1].
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