Danicopan
CAS No. : 1903768-17-1
(Synonyms: ACH-4471)
| Size | Price | Stock |
|---|---|---|
| 1mg | $130 | In-stock |
| 5mg | $275 | In-stock |
| 10mg | $418 | In-stock |
| 25mg | $737 | In-stock |
| 50mg | $1089 | In-stock |
| 100mg | $1639 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117930 |
| M.Wt: | 580.41 |
| Formula: | C26H23BrFN7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1]. IC50 & Target:Kd: 0.54 nM (Factor D)[1] In Vitro:Danicopan (ACH-4471) inhibits the proteolytic activity of purified Factor D against its natural substrate Factor B in complex with C3b, blocking production of Bb fragment in a dose-dependent manner with an IC50 value of 0.015 μM[1]. Danicopan (ACH-4471) potently inhibits hemolysis with IC50 values ranging from 0.0040 μM to 0.027 μM (IC90 values from 0.015 μM to 0.11 μM)[1].
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