GSK2879552 (dihydrochloride)
CAS No. : 1902123-72-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18632A |
| M.Wt: | 437.40 |
| Formula: | C23H30Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 31.25 mg/mL (ultrasonic) |
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2]. In Vitro: GSK2879552 inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuates stemness properties. GSK2879552 depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells[1]. In Vivo: GSK2879552 (1.5 mg/kg, p.o.) treatment exhibits tumor growth inhibition in SCLC xenograft bearing mice[2].
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