Sodium citrate monobasic
CAS No. : 18996-35-5
(Synonyms: Citric acid monosodium salt)
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| Cat. No. : | HY-W008606 |
| M.Wt: | 214.11 |
| Formula: | C6H7NaO7 |
| Purity: | >98 % |
| Solubility: |
Sodium citrate monobasic (Citric acid monosodium salt) is a natural preservative and food tartness enhancer. Sodium citrate monobasic induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Sodium citrate monobasic cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Sodium citrate monobasic is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries[1][2][3][4].
In Vitro:Sodium citrate monobasic (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3].
Sodium citrate monobasic (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Sodium citrate monobasic (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].
In Vivo:Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1].
Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].
Sodium citrate monobasic (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2].
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