Chlorothalonil


CAS No. : 1897-45-6

1897-45-6
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Cat. No. : HY-N6625
M.Wt: 265.91
Formula: C8Cl4N2
Purity: >98 %
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Introduction of 1897-45-6 :

Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity[1][2][3][4][5]. In Vitro:Chlorothalonil (10mg/kg soil) inhibits the activity of phosphatase and dehydrogenase activity in soil, reduces the number of microorganisms in soil[3].
Chlorothalonil (0.6-4.8 µg/mL; 4 days) induces intestinal epithelial barrier (IEB) dysfunction in Caco-2 cells by activating the mitogen-activated protein kinase (MAPK) pathway[4].
Chlorothalonil (0.1-10 μM; 4 h and 24 h) reduces porcine sperm motility and increases apoptosis in a concentration- and time-dependent manner[5].
In Vivo:Chlorothalonil (400-600 mg/kg; p.o.; Once daily for 18 days) produces toxicity and fetal toxicity in pregnant ICR mice[1].
Chlorothalonil (0.1-10 mg/kg; p.o.; Once daily for 5 weeks) reduces sperm motility and inhibits spermatogenesis in ICR mice[6].

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