Endomorphin 1
CAS No. : 189388-22-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $77 | In-stock |
| 25mg | $132 | In-stock |
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| Cat. No. : | HY-P0185 |
| M.Wt: | 610.70 |
| Formula: | C34H38N6O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties[1][2][4].
IC50 & Target:Ki: 20-30 nM (kappa3 opioid receptor)[1]
In Vitro:Endomorphin 1 inhibits Forskolin (HY-15371) (1 μM) stimulated cyclic AMP formation with a pIC50 value of 8.03 in In CHOμ cells[5].
Endomorphin 1 (1-10 μM) increases interleukin-8 secretion in Caco-2 cells[6].
Endomorphin 1 (1 μM) inhibits excitatory transmission in adult rat substantia gelatinosa neurons[7].
In Vivo:Endomorphin 1 (i.c.v.) shows antinociceptive properties in mice, with an ED50 value of 6.16 nM[2].
Endomorphin 1 (50 μg/kg, i.v.) alleviates myocardial ischemia/reperfusion injury (MIRI) by inhibiting the inflammatory response[3].
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