OPC 33540
CAS No. : 189362-27-4
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| Cat. No. : | HY-112631 |
| M.Wt: | 469.62 |
| Formula: | C27H39N3O4 |
| Purity: | >98 % |
| Solubility: |
OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies[1]. In Vitro:OPC-33540 (0.1-100 nM) exhibits concentration-dependent increase in platelet cAMP levels and strongly inhibits platelet aggregation induced by thrombin[1].
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