Proquinazid
CAS No. : 189278-12-4
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| Cat. No. : | HY-117171 |
| M.Wt: | 372.21 |
| Formula: | C14H17IN2O2 |
| Purity: | >98 % |
| Solubility: |
Proquinazid is a Bcl-2 and PCNA modulator, oxidative stress inducer, genotoxin and apoptosis inducer. Proquinazid causes DNA damage and also triggers apoptosis by regulating pro-apoptotic and anti-apoptotic proteins[1]. In Vivo:Proquinazid (1-8 mg/kg bw/day; p.o.; daily; 28 days) induces dose-dependent hepatotoxicity and nephrotoxicity in male Wistar rats via oxidative stress, genotoxic damage, and apoptotic cell death, with significant effects observed even at the 1 mg/kg bw/day dose[1].
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