PF-06747711
CAS No. : 1892576-58-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $125 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $435 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112706 |
| M.Wt: | 497.51 |
| Formula: | C26H26F3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic) |
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1]. IC50 & Target: IC50: 4.1 nM (RORC2)[1] In Vitro: PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM[1]. In Vivo: PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice[1].
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