Lapaquistat acetate
CAS No. : 189060-13-7
(Synonyms: TAK-475)
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| 5mg | $400 | In-stock |
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| Cat. No. : | HY-16274 |
| M.Wt: | 645.14 |
| Formula: | C33H41ClN2O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway[1]. Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research[2]. IC50 & Target: Squalene synthase[1] In Vivo: Lapaquistat acetate (diet supplemented; 100 or 200 mg/kg; 32 weeks) decreases plasma cholesterol and triglyceride levels. It delays progression of coronary atherosclerosis and changes coronary atheromatous plaques from unstable, macrophage/lipid accumulation-rich, lesions to stable fibromuscular lesions in vivo[3].
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