Lapaquistat
CAS No. : 189059-71-0
(Synonyms: T-91485)
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $820 | In-stock |
| 10mg | $1400 | In-stock |
| 25mg | $2800 | In-stock |
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| Cat. No. : | HY-14925 |
| M.Wt: | 603.10 |
| Formula: | C31H39ClN2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1].
IC50 & Target:Cholesterol biosynthesis[1]
In Vitro: Lapaquistat inhibits cholesterol biosynthesis in differentiated RD (rhabdomyosarcoma) cells, with an IC50 of 36 nM[1].
Lapaquistat potently inhibits cholesterol synthesis in RD cells, with an IC25 exceeded 100 μM[1].
Lapaquistat concentration-dependently inhibits cholesterol biosynthesis in human skeletal myocytes, with an IC50 of 45 nM[1].
In Vivo: After oral administration to rats, Lapaquistat acetate (HY-16274) is absorbed and rapidly hydrolyzed into a pharmacological active metabolite, Lapaquistat[1].
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