UPGL00004
CAS No. : 1890169-95-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $288 | In-stock |
| 50mg | $432 | In-stock |
| 100mg | $648 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119377 |
| M.Wt: | 534.66 |
| Formula: | C25H26N8O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].
IC50 & Target: IC50: 29 nM (Glutaminase C)[1]
Kd: 27 nM (Glutaminase C)[1]
In Vitro: UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1].
In Vivo: The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model[1].
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