Cilengitide (Standard)
CAS No. : 188968-51-6
(Synonyms: EMD 121974 (Standard))
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| Cat. No. : | HY-16141R |
| M.Wt: | 588.66 |
| Formula: | C27H40N8O7 |
| Purity: | >98 % |
| Solubility: |
Cilengitide (Standard) is the analytical standard of Cilengitide. This product is intended for research and analytical applications. Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers[1][2][3]. IC50 & Target:IC50: 0.61 nM (αvβ3), 8.4 nM (αvβ5), 14.9 nM (α5β1)[1]; 4 nM (αvβ3/Vitronectin), 79 nM (αvβ5/Vitronectin)[2]
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