Cl-4AS-1
CAS No. : 188589-66-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $179 | In-stock |
| 5mg | $358 | In-stock |
| 10mg | $500 | In-stock |
| 25mg | $890 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $1850 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103245 |
| M.Wt: | 441.01 |
| Formula: | C26H33ClN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].
IC50 & Target: IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]
In Vitro: Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].
In Vivo: Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].
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