Cbz-B3A
CAS No. : 1884710-81-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $146 | In-stock |
| 5mg | $322 | In-stock |
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| Cat. No. : | HY-114267 |
| M.Wt: | 706.87 |
| Formula: | C35H58N6O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming) |
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
IC50 & Target:mTORC1 signaling[1].
In Vitro: Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.
Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins.
Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of ~3 μM.
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