NI-42
CAS No. : 1884640-99-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $251 | In-stock |
| 50mg | $376 | In-stock |
| 100mg | $564 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101121 |
| M.Wt: | 353.40 |
| Formula: | C18H15N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins[1].
IC50 & Target: IC50: 7.9/48/260 nM (BRPF1/2/3), 82/310 nM (BRD7/9), 4500 nM (BRD4 (BD1))[1]
Kd: 40/210/940 nM (BRPF1/2/3), 1130 nM (BRD9)[1]
In Vitro: NI-42 shows IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively, and has a Kd of 1130 nM for BRD9[1].
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