SBI-0206965
CAS No. : 1884220-36-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $77 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $605 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16966 |
| M.Wt: | 489.32 |
| Formula: | C21H21BrN4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation[1][2][3].
IC50 & Target:IC50: 108 nM (ULK1 kinase), 711 nM (ULK2 kinase)[2]
In Vitro:SBI-0206965 (5-20 μM; 24 hours) induces apoptosis of A498 and ACHN cells during starvation[1].
SBI-0206965 (5-20 μM; 24 hours) attenuates the phosphorylation of Ser108 of the AMPK β1 subunit and increases the levels of cleaved Caspase 8 and PARP, markers of apoptosis[1].
In Vivo:SBI-0206965 (50 mg/kg; i.p.; once every 3 days for 37 days) inhibites tumour growth and induces apoptosis in A498 xenograft tumours[1].
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