MAFP
CAS No. : 188404-10-6
(Synonyms: Methyl Arachidonyl Fluorophosphonate)
| Size | Price | Stock |
|---|---|---|
| 26.99 mM * 1 mL in Methyl acetate | $242 | In-stock |
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| Cat. No. : | HY-103334 |
| M.Wt: | 370.48 |
| Formula: | C21H36FO2P |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase. IC50 & Target:cPLA2, iPLA2[1], Anandamide amidase[2] In Vitro:MAFP inhibits iPLA2, in a concentration-dependent manner with an IC50 of 0.5 μM after a 5 min preincubation at 40°C in P388D1 cells. cPLA, is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile[1]. MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP demonstrates selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. MAFP displaces [3H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide[2].
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