Tapotoclax
CAS No. : 1883727-34-1
(Synonyms: AMG-176)
| Size | Price | Stock |
|---|---|---|
| 1mg | $580 | In-stock |
| 5mg | $1950 | In-stock |
| 10mg | $2650 | In-stock |
| 25mg | $3980 | In-stock |
| 50mg | $5460 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-101565 |
| M.Wt: | 613.21 |
| Formula: | C33H41ClN2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2]. IC50 & Target: Ki: 0.13 nM (MCL1)[1][2]. In Vitro: Tapotoclax is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, Tapotoclax binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2].
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