IACS-9571 (TFA)
CAS No. : 1883598-69-3
(Synonyms: ASIS-P040 (TFA))
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| Cat. No. : | HY-102000A |
| M.Wt: | 756.79 |
| Formula: | C34H43F3N4O10S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
IACS-9571 (trifluoroacetate) is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kd of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
IC50 & Target:IC50: 8 nM (TRIM24)[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)[1]
In Vitro: IACS-9571 (trifluoroacetate) shows excellent cellular potency with EC50 of 50 nM. IACS-9571 (trifluoroacetate) (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 (trifluoroacetate) is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 (trifluoroacetate) does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4 (1, 2) relative to TRIM24[1].
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