GPR4 antagonist 2
CAS No. : 1883333-94-5
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| Cat. No. : | HY-101537 |
| M.Wt: | 479.67 |
| Formula: | C31H37N5 |
| Purity: | >98 % |
| Solubility: |
GPR4 antagonist 2 is a selective GPR4 antagonist with an IC50 of 67 nM. GPR4 antagonist 2 inhibits pH-dependent GPR4 activation and CRE-driven transcriptional activity. GPR4 antagonist 2 prolongs the survival of mice in a myocardial infarction model. GPR4 antagonist 2 can be used for research on myocardial infarction[1].
In Vitro:GPR4 antagonist 2 (compound 3b) (10 μM) is a potent antagonist of pH-dependent GPR4 activation in HEK293 cells expressing GPR4, with a CRE activity ratio of 0.39 and an IC50 of 67 nM[1].
GPR4 antagonist 2 (10 μM) shows no activity against TDAG8 or OGR1 in HEK293 cells expressing these receptors[1].
In Vivo:GPR4 antagonist 2 (compound 3b) (6.7 mg/kg/day; i.p.; twice daily) achieves a 100% mouse survival rate in a mouse myocardial infarction model[1].
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